ACTIVITATE DE CERCETARE

I. Cursuri, manuale de specialitate şi monografii (cărți)

IA. Cărți apărute în edituri internaționale/naționale- recunoscute CNCS

1. Klinikai kardiológia: jegyzet. Benedek Imre, Bajka Balázs, Benedek Theodora, 2015, Editura Universității Oradea, ISBN 978-606-10-1731-7

2. ANGIO COMPUTER TOMOGRAFIA MULTISCLICE ÎN DIAGNOSTICUL BOLILOR CARDIOVASCULARE. Benedek Imre, Benedek Theodora. 2014, Editura Universității Oradea, ISBN 978-606-10-1228-2

3. TRIALURI CLINICE MAJORE ÎN CARDIOLOGIE. Benedek Theodora, Benedek Imre, Chițu Monica, Kovács István, Benedek István jr. 2014, Editura Universității Oradea, ISBN 978-606-10-1227-5

4. Recuperare cardiovasculară : note de curs. Benedek Theodora, Chitu Monica, Benedek Imre. 2014, Târgu-Mureș : University Press, ISBN : 978-973-169-284-5.

5. Benedek Imre – Insuficienta cardiaca din cardiomiopatiile dilatative Publisher - Editura Didactica si Pedagogica, Bucuresti, 2005, ISBN – 973-30-1054-5, 236 pages

6. Benedek Imre – Biopsia endomiocardica Publisher - Editura Interval, Cluj-Napoca – 1998, ISBN – 973-98374-5-X, 57 pages

7. Benedek Imre – Aportul tehnicilor imagistice in diagosticul si tratamentul bolilor arteriale obstructive periferice, Publisher - Editura Interval, Cluj-Napoca – 1998, ISBN – 973-98374-6-8, 152 pages

8. Benedek Imre – Actualitati in bolile arteriale obstructive periferice Publisher - Editura Gloria, Cluj-Napoca – 1997, ISBN – 973-9203-24-8, 218 pages

9. Jako Beata, Kovacs Istvan, Rat Nora. Kutatasmodszertan Jegyzet. Editura Universitatii din Oradea – 2015, ISBN 978-606-10-1732-4

Capitole de cărți în volume colective
1.   Advances in multimodal monitoring in the critically ill patient. Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Dorel Sandesc, 2016, ed. Lambert Academic Publishing, ISBN: 978-659-96924-9. Capitolul: ICU patient monitoring following acute myocardial infarction. Monica Chitu, Benedek Imre, Benedek Theodora. Pg 42-60
2.   Advances in multimodal monitoring in the critically ill patient. Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Dorel Sandesc, 2016, ed. Lambert Academic Publishing, ISBN: 978-659-96924-9. Capitolul: Biomarkers in acute heart failure. Imre Benedek, Chitu Monica, Benedek Theodora. Pg 61-74.
3.   Progrese in cardiologie 2012. Societatea Romana de Cardiologie. Editie ingrijita de Conf. Dr. Ioan Mircea Coman – Media Med Publicis, 2012 ISSN 1843-3731. Capitolul: Noi perspective in asistarea imagistica a tratamentului interventional. Benedek Imre, Benedek Theodora – Grupul de lucru de Cardiologie Inteventionala

IB. Cursuri de specialitate

1.   Curs de Medicina interna – Cardiologie – Pentru studentii de la medicina an IV, Benedek Theodora, Benedek Imre, 2013
2.   Course of Interventional Cardiology, Benedek Theodora, Benedek Imre, 2013
3.   Curs de Medicină Internă Pentru Medicină Dentară, Benedek Theodora, Benedek Imre, 2013
4.   Curs de Recuperare Cardiovasculară Pentru studenții de la specilizarea balneofizioterapie, Benedek Theodora, Chițu Monica, Benedek Imre, 2013
5.   Belgyógyászat Kurzus - Kardiológia – IV. Éves orvostanhallgatók számára, Benedek Imre, Benedek Theodora, 2013
6.   Intervencionális Kardiológia Kurzus V. Éves orvostanhallgatók számára, Benedek Imre, Benedek Theodora, 2013
7.   Belgyógyászat Kurzus Általános Orvosi Asszisztens, Bábaképző, Benedek Imre, Benedek Theodora, 2013

II. Lista de articole științifice publicate in extenso

IIa. Lista de articole științifice publicate in extenso în ISI Web of Science (cu nr. de citari din ISI Web of Science)

1. Nyolczas N, Gyöngyösi M, Beran G, Dettke M, Graf S, Sochor H, Christ G, Edes I, Balogh L, Krause KT, Jaquet K, Kuck KH, Benedek I, Hintea T, Kiss R, Préda I, Kotevski V, Pejkov H, Dudek D, Heba G, Sylven C, Charwat S, Jacob R, Maurer G, Lang I, Glogar D. Design and rationale for the Myocardial Stem Cell Administration After Acute Myocardial Infarction (MYSTAR) Study: a multicenter, prospective, randomized, single-blind trial comparing early and late intracoronary or combined (percutaneous intramyocardial and intracoronary) administration of nonselected autologous bone marrow cells to patients after acute myocardial infarction. Am Heart J. 2007 Feb;153(2):212.e1-7. DOI: 10.1016/j.ahj.2006.10.027 FI 3,649

2. Gyöngyösi M, Lang I, Dettke M, Beran G, Graf S, Sochor H, Nyolczas N, Charwat S, Hemetsberger R, Christ G, Edes I, Balogh L, Krause KT, Jaquet K, Kuck KH, Benedek I, Hintea T, Kiss R, Préda I, Kotevski V, Pejkov H, Zamini S, Khorsand A, Sodeck G, Kaider A, Maurer G, Glogar D. Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction: the MYSTAR prospective, randomized study. Nat Clin Pract Cardiovasc Med. 2009 Jan;6(1):70-81. doi: 10.1038/ncpcardio1388. FI 5,902

3. Gyöngyösi M, Hemetsberger R, Posa A, Charwat S, Pavo N, Petnehazy O, Petrasi Z, Pavo IJ, Hemetsberger H, Benedek I, Benedek T, Benedek I Jr, Kovacs I, Kaun C, Maurer G. Hypoxia-inducible factor 1-alpha release after intracoronary versus intramyocardial stem cell therapy in myocardial infarction. J Cardiovasc Transl Res. 2010 Apr;3(2):114-21. doi: 10.1007/s12265-009-9154-1. FI 0,495

4. Mariann Gyongyosi, Rayyan Hemetsberger, Susanne Wolbank, Valentin Pichler, Cristoph Kaun, Aniko Posa, Zsolt Petrasi, Ors Petnehazy, Renate Hofer-Warbinek, Rainer de Martin, Florian Gruber, Imre Benedek, Theodora Benedek, Istvan Kovacs, Istvan Benedek jr., Christian A.Plass, Silvia Charwat, Gerald Maurer – Delayed Recovery of Myocardial Blood Flow After Intracoronary Stem Cell Administration. Stem Cell Review and Reports, 2011;7:616-623, ISSN 1550-8943 doi: 10.1007/s12015-010-9213-7. FI 3,739

5. Benedek T, Gyöngyösi M, Benedek I. Multislice computed tomographic coronary angiography for quantitative assessment of culprit lesions in acute coronary syndromes. Can J Cardiol. 2013 Mar;29(3):364-71. doi: 10.1016/j.cjca.2012.11.004. FI 3,940

6. Benedek Imre, Gyongyosi Mariann, Benedek Theodora*. A prospective regional registry of ST-elevation myocardial infarction in Central Romania: Impact of the Stent for Life Initiative recommendations on patient outcomes. American Heart Journal 2013; 166 (3):457-465, ISSN 0002-8703. doi: 10.1016/j.ahj.2013.03.033. FI 4,555

7. Benedek Theodora, Jako Beata, Benedek Imre. Plaque Quantification by Coronary CT and Intravascular Ultrasound Identifies a Low CT Density Core as a Marker of Plaque Instability in Acute Coronary Syndromes. International Heart Journal, 2014, 55(1): 22-29, ISSN 1349-2365. FI 1,073

8. Benedek Imre, Bucur Oana, Benedek Theodora. Intracoronary infusion of mononuclear bone marrow derived stem cells is associated with lower plaque burden after four years. Journal of Atherosclerosis and Thrombosis, 2014, 15(8):88, ISSN 1340–3478. FI 2,733

9. Benedek Theodora, Matei Marius, Benedek Imre. Giant aneurysm of the Valsalva sinus associated with multiple coronary artery aneurysms and patent ductus arteriosus. European Heart Journal, 2014;35(11):69. doi: 10.1093/eurheartj/eht417. FI 15,203

10. Benedek Theodora, Chitu Monica, Benedek Imre - Response to Relationship of Race/Ethnicity with Door-to-Balloon Tima and Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction – Findings From Get With the Guidelines – Coronary Artery Disease. Clinical Cardiology, 2014; 37:322-323, ISSN 0160-9289, doi: 10.1002/clc.22266. FI 2,586

11. Rodica Toganel, Theodora Benedek*, Imre Benedek. Giant mycotic pulmonary artery aneurysm in a newborn. European Heart Journal Cardiovascular Imaging, 2014;15(8):885, ISSN 2047-2404 doi: 10.1007/s00380-013-0445-8. FI 4,105

12. Pavo N, Charwat S, Nyolczas N, Jakab A, Murlasits Z, Bergler-Klein J, Nikfardjam M, Benedek I, Benedek T, Pavo IJ, Gersh BJ, Huber K, Maurer G, Gyöngyösi M. Cell therapy for human ischemic heart diseases: critical review and summary of the clinical experiences. J Mol Cell Cardiol. 2014 Oct;75:12-24. doi: 10.1016/j.yjmcc.2014.06.016. FI 4,655

13. Rodica Toganel, Theodora Benedek*, Carmen Suteu, Imre Benedek. Aneurysmal aorto-left ventricular tunnel causing right ventricular outflow tract obstruction, associated with bicuspid aortic valve - a case report. Heart & Vessels, 2015; 30:140-142. doi: 10.1007/s00380-013-0445-8. FI 2,293

14. Suciu Z, Benedek T, Benedek I. Response to the paper by Jiang et al. entitled 'Prognostic value of cardiac computed tomography angiography in patients with suspected coronary artery disease: a meta-analysis'. Cardiology. 2015;130(1):15-16. doi: 10.1159/000365964. FI 1,994

15. Gyöngyösi M, Wojakowski W, Lemarchand P, Lunde K, Tendera M, Bartunek J, Marban E, Assmus B, Henry TD, Traverse JH, Moyé LA, Sürder D, Corti R, Huikuri H, Miettinen J, Wöhrle J, Obradovic S, Roncalli J, Malliaras K, Pokushalov E, Romanov A, Kastrup J, Bergmann MW, Atsma DE, Diederichsen A, Edes I, Benedek I, Benedek T, Pejkov H, Nyolczas N, Pavo N, Bergler-Klein J, Pavo IJ, Sylven C, Berti S, Navarese EP, Maurer G; ACCRUE Investigators. Meta-Analysis of Cell-based CaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res. 2015 Apr 10;116(8):1346-60. doi: 10.1161/CIRCRESAHA.116.304346. FI 11,551

16. Tiberiu Nyulas, Theodora Benedek, Claudia Matei, István Kovács, Monica Chițu, Szillamér Korodi, Imre Benedek. Correlation Between Acute Impairment of Regional Contractility and Left Ventricular Remodeling after Revascularized Acute Myocardial Infarction. Journal of Cardiovascular Emergencies 2015;1(1):35-41 DOI: 1515/jce-2015-006

17. Marius Orzan, Theodora Benedek, Balázs Bajka, Kinga Pál, Nora Rat, Imre Benedek. Impact of a Preexisting STEMI Network in Improving STEMI Diagnostic and Treatment in the Community after the Introduction of a National Program of Interventional Treatment in Acute Myocardial Infarction. Journal of Cardiovascular Emergencies 2015;1(1):23-28. DOI: 10.1515/jce-2015-0004

18. Feger S, Ibes P, Napp AE, Lembcke A, Laule M, Dreger H, Bokelmann B, Davis GK, Roditi G, Diez I, Schröder S, Plank F, Maurovich-Horvat P, Vidakovic R, Veselka J, Ilnicka-Suckiel M, Erglis A, Benedek T, Rodriguez-Palomares J, Saba L, Kofoed KF, Gutberlet M, Ađić F, Pietilä M, Faria R, Vaitiekiene A, Dodd JD, Donnelly P, Francone M, Kepka C, Ruzsics B, Müller-Nordhorn J, Schlattmann P, Dewey M. Clinical pre-test probability for obstructive coronary artery disease: insights from the European DISCHARGE pilot study. Eur Radiol. 2020 Sep 9. doi: 10.1007/s00330-020-07175-z. FI 4,101

19. Lazou A, Ikonomidis I, Bartekova M, Benedek T, Makavos G, Palioura D, Cabrera Fuentes H, Andreadou I. Chronic inflammatory diseases, myocardial function and cardioprotection. Br J Pharmacol. 2020 Dec;177(23):5357-5374. doi: 10.1111/bph.14975. FI 7,73

20. Benedek T. Multi-Modality Cardiac Imaging in Interventional Cardiology. Curr Med Imaging Rev. 2020;16(2):95-97. doi: 10.2174/157340561602200124090520. FI 0,812

21. Benedek A, Cernica D, Mester A, Opincariu D, Hodas R, Rodean I, Keri J, Benedek T. Modern Concepts in Regenerative Therapy for Ischemic Stroke: From Stem Cells for Promoting Angiogenesis to 3D-Bioprinted Scaffolds Customized via Carotid Shear Stress Analysis. Int J Mol Sci. 2019 May 25;20(10):2574. doi: 10.3390/ijms20102574. FI 4,556

22. Molnar C, Opincariu D, Benedek T, Toma M, Nicolescu C. Association between varicose veins anatomical pattern and procedural complications following endovascular laser photothermolysis for chronic venous insufficiency. Braz J Med Biol Res. 2019 Apr 8;52(4):e8330. doi: 10.1590/1414-431X20198330. FI 2,023

24. Benedek T, Opincariu D, Rat N, Hodas R, Mester A, Benedek I. The Assessment of Epicardial Adipose Tissue in Acute Coronary Syndrome Patients. A Systematic Review. Journal of Cardiovascular Emergencies. 2017;3:18-29. DOI: 10.1515/jce-2017-0003.

25. Blesneac C, Horvath E, Muntean I, Benedek T, Toganel R. Intracardiac bronchogenic cyst associated with ventricular septal defect: an extremely rare feature in children. Eur Heart J Cardiovasc Imaging. 2018 Sep 1;19(9):1074. doi: 10.1093/ehjci/jey078. FI 4,841

26. Gozar H, Derzsi Z, Chira A, Nagy Ö, Benedek T. Finite-element-based 3D computer modeling for personalized treatment planning in clubfoot deformity: Case report with technique description. Medicine (Baltimore). 2018 Jun;97(24):e11021. doi: 10.1097/MD.0000000000011021. FI 1,087

27. Muntean I, Benedek T, Togănel R. Right ventriculo-arterial coupling in heart failure - Is the right ventricle independent? Int J Cardiol. 2018 May 15;259:136. doi: 10.1016/j.ijcard.2017.12.062. FI 3,229

28. Benedek T, Kovács I, Benedek I. Therapeutic Angiogenesis for Severely Ischemic Limbs — from Bench to Bedside in Acute Vascular Care. Journal of Cardiovascular Emergencies 2017;3(4):160-171. DOI: 10.1515/jce-2017-0028.

29. Cucuruzac R, Muntean I, Benedek I, Mester A, Rat N, Mitre A, Chitu M, Benedek T. Right Ventricle Remodeling and Function in Scleroderma Patients. Biomed Res Int. 2018;2018:4528148. doi: 10.1155/2018/4528148. FI 2,197

30. Nyulas T, Marton E, Rus VA, Rat N, Ratiu M, Benedek T, Benedek I. Morphological Features and Plaque Composition in Culprit Atheromatous Plaques of Patients with Acute Coronary Syndromes. JOURNAL OF CARDIOVASCULAR EMERGENCIES. Volume: 4 Issue: 2 Pages: 84-94
DOI: 10.2478/jce-2018-0012

31. Theodora Benedek, Ioana Rodean, Mihaela Ratiu, Nora Rat, Lia Yero Eremie, Carmen Biriș, Luminița Lazăr, Mariana Păcurar, Imre Benedek. Periodontal Disease, Inflammation and Atherosclerosis Progression in Patients with Acute Coronary Syndromes – the ATHERODENT Study. Journal of Cardiovascular Emergencies. 2018;4:17-23. DOI: 10.2478/jce-2018-0001

32. Jeremias Z, Rat N, Benedek I, Rapolti E, Ratiu M, Muresan A, Benedek T. High iliac calcium score is associated with increased severity and complexity of peripheral arterial disease and predicts global atherosclerotic burden. Vasa. 2018 Aug;47(5):377-386. doi: 10.1024/0301-1526/a000718. FI 1,534

33. Szabó M, Máté B, Csép K, Benedek T. Epigenetic Modifications Linked to T2D, the Heritability Gap, and Potential Therapeutic Targets. Biochem Genet. 2018 Dec;56(6):553-574. doi: 10.1007/s10528-018-9863-8. FI 2,027

34. Ratiu M, Chitu M, Benedek I, Benedek T, Kovacs I, Rat N, Rezus C. Impact of coronary plaque geometry on plaque vulnerability and its association with the risk of future cardiovascular events in patients with chest pain undergoing coronary computed tomographic angiography - the GEOMETRY study Protocol for a prospective clinical trial. Medicine (Baltimore). 2018;97(49):e13498. doi: 10.1097/MD.0000000000013498. FI 1,087

35. Szabo M, Máté B, Csép K, Benedek T. Genetic Approaches to the Study of Gene Variants and Their Impact on the Pathophysiology of Type 2 Diabetes. Biochem Genet. 2018 Apr;56(1-2):22-55. doi: 10.1007/s10528-017-9827-4. FI 2,027

36. Ratiu M, Rat N, Nyulas T, Moldovan G, Rus V, Benedek T, Benedek I. Coronary Plaque Geometry and Thoracic Fat Distribution in Patients with Acute Chest Pain - a CT Angiography Study. JOURNAL OF CARDIOVASCULAR EMERGENCIES, Volume: 5 Issue: 1 Pages: 18-24
DOI: 10.2478/jce-2019-0001

37. Korodi S, Toganel R, Benedek T, Hodas R, Chitu M, Ratiu M, Kovacs I, Mester A, Benedek I. Impact of inflammation-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation - the FIBRO-RISK study Protocol for a non-randomized clinical trial. Medicine (Baltimore). 2019;98(9):e14504. doi: 10.1097/MD.0000000000014504. FI 1,087

38. Lazar E, Benedek T, Korodi S, Rat N, Lo J, Benedek I. Stem cell-derived exosomes - an emerging tool for myocardial regeneration. World J Stem Cells. 2018;10(8):106-115. doi: 10.4252/wjsc.v10.i8.106. FI 3,534

39. Morariu M, Hodas R, Benedek T, Benedek I, Opincariu D, Mester A, Chitu M, Kovacs I, Rezus C, Pasaroiu D, Mitra N, Szilágyi SM, Georgescu D, Rezus E. Impact of inflammation-mediated response on pan-coronary plaque vulnerability, myocardial viability and ventricular remodeling in the postinfarction period - the VIABILITY study: Protocol for a non-randomized prospective clinical study. Medicine (Baltimore). 2019 Apr;98(17):e15194. doi: 10.1097/MD.0000000000015194. FI 1,087

40. Rus VA, Chitu M, Cernea S, Benedek I, Hodas R, Zavate R, Nyulas T, Hintea M, Benedek T. Altered nutritional status, inflammation and systemic vulnerability in patients with acute myocardial infarction undergoing percutaneous coronary revascularisation: A prospective study in a level 3 cardiac critical care unit. Nutr Diet. 2019 May 7. doi: 10.1111/1747-0080.12536. [Epub ahead of print] FI 1,742

41. Opincariu D, Benedek T, Chițu M, Raț N, Benedek I. From CT to artificial intelligence for complex assessment of plaque-associated risk. Int J Cardiovasc Imaging. 2020 Dec;36(12):2403-2427. doi: 10.1007/s10554-020-01926-1. FI 1,969

42. Rapolti E, Opincariu D, Benedek I, Kovacs I, Ratiu M, Rat N, Benedek T. Computer-Aided Biomedical Imaging of Periiliac Adipose Tissue Identifies Perivascular Fat as a Marker of Disease Complexity in Patients with Lower Limb Ischemia. APPLIED SCIENCES-BASEL. 2020;10(13):4456. DOI: 10.3390/app10134456. FI 2,474

43. Rieckmann N, Neumann K, Feger S, Ibes P, Napp A, Preuß D, Dreger H, Feuchtner G, Plank F, Suchánek V, Veselka J, Engstrøm T, Kofoed KF, Schröder S, Zelesny T, Gutberlet M, Woinke M, Maurovich-Horvat P, Merkely B, Donnelly P, Ball P, Dodd JD, Hensey M, Loi B, Saba L, Francone M, Mancone M, Berzina M, Erglis A, Vaitiekiene A, Zajanckauskiene L, Harań T, Suckiel MI, Faria R, Gama-Ribeiro V, Benedek I, Rodean I, Adjić F, Čemerlić Adjić N, Rodriguez-Palomares J, Garcia Del Blanco B, Brooksbank K, Collison D, Davis G, Thwaite E, Knuuti J, Saraste A, Kępka C, Kruk M, Benedek T, Ratiu M, Neskovic AN, Vidakovic R, Diez I, Lecumberri I, Fisher M, Ruzsics B, Hollingworth W, Gutiérrez-Ibarluzea I, Dewey M, Müller-Nordhorn J. Health-related qualify of life, angina type and coronary artery disease in patients with stable chest pain. Health Qual Life Outcomes. 2020 May 14;18(1):140. doi: 10.1186/s12955-020-01312-4. Erratum in: Health Qual Life Outcomes. 2020 Jun 29;18(1):205. FI 2,344

44. De Rubeis G, Napp AE, Schlattmann P, Geleijns J, Laule M, Dreger H, Kofoed K, Sørgaard M, Engstrøm T, Tilsted HH, Boi A, Porcu M, Cossa S, Rodríguez-Palomares JF, Xavier Valente F, Roque A, Feuchtner G, Plank F, Štěchovský C, Adla T, Schroeder S, Zelesny T, Gutberlet M, Woinke M, Károlyi M, Karády J, Donnelly P, Ball P, Dodd J, Hensey M, Mancone M, Ceccacci A, Berzina M, Zvaigzne L, Sakalyte G, Basevičius A, Ilnicka-Suckiel M, Kuśmierz D, Faria R, Gama-Ribeiro V, Benedek I, Benedek T, Adjić F, Čanković M, Berry C, Delles C, Thwaite E, Davis G, Knuuti J, Pietilä M, Kepka C, Kruk M, Vidakovic R, Neskovic AN, Lecumberri I, Diez Gonzales I, Ruzsics B, Fisher M, Dewey M, Francone M; DISCHARGE Trial Group. Pilot study of the multicentre DISCHARGE Trial: image quality and protocol adherence results of computed tomography and invasive coronary angiography. Eur Radiol. 2020 Apr;30(4):1997-2009. doi: 10.1007/s00330-019-06522-z. Epub 2019 Dec 16. Erratum in: Eur Radiol. 2020 Sep;30(9):5223-5225.; FI 4,101

45. Susca MG, Hodas R, Benedek T, Benedek I, Chitu M, Opincariu D, Chiotoroiu A, Rezus C. Impact of cardiac rehabilitation programs on left ventricular remodeling after acute myocardial infarction: Study Protocol Clinical Trial (SPIRIT Compliant). Medicine (Baltimore). 2020 Apr;99(16):e19759. doi: 10.1097/MD.0000000000019759. FI 1,552

46. Nyulas T, Chițu M, Benedek T. Plaque vulnerability, post-PCI tissue prolapse and neoatherosclerosis. Int J Cardiol. 2017 Dec 15;249:502. doi: 10.1016/j.ijcard.2017.08.015. FI 3,229

47. Morariu M, Hodas R, Benedek T, Benedek I, Opincariu D, Mester A, Chitu M, Kovacs I, Rezus C, Pasaroiu D, Mitra N, Szilágyi SM, Georgescu D, Rezus E. Impact of inflammation-mediated response on pan-coronary plaque vulnerability, myocardial viability and ventricular remodeling in the postinfarction period - the VIABILITY study: Protocol for a non-randomized prospective clinical study. Medicine (Baltimore). 2019 Apr;98(17):e15194. doi: 10.1097/MD.0000000000015194. FI 1,552

48. Korodi S, Toganel R, Benedek T, Hodas R, Chitu M, Ratiu M, Kovacs I, Mester A, Benedek I. Impact of inflammation-mediated myocardial fibrosis on the risk of recurrence after successful ablation of atrial fibrillation - the FIBRO-RISK study: Protocol for a non-randomized clinical trial. Medicine (Baltimore). 2019 Mar;98(9):e14504. doi: 10.1097/MD.0000000000014504. FI 1,552

49. Muntean I, Togănel R, Benedek T. Genetics of Congenital Heart Disease: Past and Present. Biochem Genet. 2017 Apr;55(2):105-123. doi: 10.1007/s10528-016-9780-7. FI 2,027

50. Vlasa A, Biris C, Benedek T, Eremie L. Letter to the Editor, "Association of Endodontic Lesions with Coronary Artery Disease". J Dent Res. 2017 Feb;96(2):233. doi: 10.1177/0022034516681953. FI 4,914

51. Suteu CC, Muntean I, Benedek T, Togănel R. Giant dissecting ventricular septal haematoma associated with critical congenital heart disease. Interact Cardiovasc Thorac Surg. 2016 Nov;23(5):837-838. doi: 10.1093/icvts/ivw223. FI 1,675

52. Muntean I, Benedek T, Melinte M, Suteu C, Togãnel R. Deformation pattern and predictive value of right ventricular longitudinal strain in children with pulmonary arterial hypertension. Cardiovasc Ultrasound. 2016 Jul 29;14(1):27. doi: 10.1186/s12947-016-0074-3. FI 2,051

53. Şuteu CC, Togănel R, Benedek T. Three Rare Anomalies of the Large Vessels in an Infant with Tetralogy of Fallot. J Card Surg. 2016 Jul;31(7):461-3. doi: 10.1111/jocs.12770. FI 1,49

54. Toganel R, Benedek T, Chitu M. Response to Statin Use and Aneurysm Risk in Patients With Bicuspid Aortic Valve Disease. Clin Cardiol. 2016 May;39(5):307-8. doi: 10.1002/clc.22543. FI 2,248

55. Bajka B, Benedek T, Molnar C. Response to Association Between Preinfarction Angina and Angiographic Findings in Non-ST-Segment Elevation Myocardial Infarction. Clin Cardiol. 2016 Mar;39(3):179. doi: 10.1002/clc.22527. FI 2,248

56. Bajka B, Benedek T, Molnar C. Commentary to the article "Coronary computed tomography angiography for the assessment of SYNTAX score". Kardiol Pol. 2016;74(1):99. doi: 10.5603/KP.2016.0015. FI 1,874

57. Benedek T, Popovici MM, Glogar D. Extracorporeal Life Support and New Therapeutic Strategies for Cardiac Arrest Caused by Acute Myocardial Infarction - a Critical Approach for a Critical Condition. J Crit Care Med (Targu Mures). 2016 Nov 8;2(4):164-174. doi: 10.1515/jccm-2016-0025

58. Benedek T, Gyöngyösi M. Out-of-Hospital Cardiac Arrest in Acute Myocardial Infarction and STEMI Networks. J Crit Care Med (Targu Mures). 2016 Feb 9;2(1):3-5. doi: 10.1515/jccm-2016-0007.

59. Licu RA, Blîndu E, Benedek I, Benedek T. Decrease of Cardiovascular Emergencies During the COVID-19 Pandemic. JOURNAL OF CARDIOVASCULAR EMERGENCIES. 2020;6(3):59-62. DOI: 10.2478/jce-2020-0011

60. Gerculy R, Libenciuc C, Rat N, Chitu M, Benedek I, Benedek T. Identical STEMI Pattern in Two Siblings with Different Risk Factors. JOURNAL OF CARDIOVASCULAR EMERGENCIES. 2020;6(3):63-66. DOI: 10.2478/jce-2020-0012

61. Benedek T. STEMI Networks in the COVID-19 Era. JOURNAL OF CARDIOVASCULAR EMERGENCIES. 2020;6(2):24-25. DOI: 10.2478/jce-2020-0009.

62. Licu RA, Blîndu E, Opincariu D, Benedek T. Vulnerable Plaques Producing an Acute Coronary Syndrome Exhibit a Different CT Phenotype than Those That Remain Silent. Journal of Cardiovascular Emergencies 2020;6:26-34. DOI: 10.2478/jce-2020-0008.

63. Benedek T. COVID-19 Pandemic and Cardiovascular Challenges. Journal of Cardiovascular Emergencies. 2020;6:5-6. DOI: 10.2478/jce-2020-0003.

64. Hodas R, Benedek T. From Chronic to Acute Models of Heart Failure – The Cost-Effectiveness Perspective. Journal of Cardiovascular Emergencies 2019;5(4):123-125. DOI: 10.2478/jce-2019-0021.

65. Benedek T, Hodas R. New ICCUs – a Modern Perspective on Acute Cardiac Care. Journal of Cardiovascular Emergencies 2019;5(2):47-49. DOI: 10.2478/jce-2019-0010

66. Benedek T. Myocardial Revascularization in Critical Patients with Acute Myocardial Infarction and Cardiogenic Shock – a Perspective on New European Recommendations. Journal of Cardiovascular Emergencies 2019;5(1):5-6. DOI: 10.2478/jce-2019-0004.

67. Mihaela Ioana Dregoesc, Adrian Corneliu Iancu, Aurelia Solomoneanu, Theodora Benedek. A Long-Forgotten Tale: The Management of Cardiogenic Shock in Acute Myocardial Infarction. Journal of Cardiovascular Emergencies 2018;4(4):170-177. DOI: 10.2478/jce-2018-0023.

68. Benedek T. The Hemodynamic Impact of Unstable Coronary Plaques — Do We Have the Evidence? Journal of Cardiovascular Emergencies 2017;3(2):59-60. DOI: 10.1515/jce-2017-0014.

69. Dobra M, Bordi L, Nyulas T, Stănescu A, Morariu M, Condrea S, Benedek T. Computed Tomography — an Emerging Tool for Triple Rule-Out in the Emergency Department. A Review. Journal of Cardiovascular Emergencies. 2017;3:36-40. DOI: 10.1515/jce-2017-0005.

70. Benedek T, Mester A, Benedek A, Rat N, Opincariu D, Chițu M. Assessment of Coronary Plaque Vulnerability in Acute Coronary Syndromes using Optical Coherence Tomography and Intravascular Ultrasound. A Systematic Review. Journal of Cardiovascular Emergencies. 2016;2:173-184. DOI: 10.1515/jce-2016-0028.

71. Benedek T, Maurovich-Horváth P, Ferdinandy P, Merkely B. The use of biomarkers for the early detection of vulnerable atherosclerotic plaques and vulnerable patients. A review. Journal of Cardiovascular Emergencies. 2016;2:106-113. DOI: 10.1515/jce-2016-0017

72. Benedek T. Pulmonary embolism — a short to long-term approach. Journal of Cardiovascular Emergencies. 2016;2:54-56. DOI: 10.1515/jce-2016-0008

73. Benedek T. Mortality reduction in acute coronary syndromes — how far are we from the goal? Journal of Cardiovascular Emergencies. 2015;1(2):54-55. DOI: 10.1515/jce-2015-0007

74. Tiberiu Nyulas, Theodora Benedek, Claudia Matei, István Kovács, Monica Chițu, Szillamér Korodi, Imre Benedek. Correlation Between Acute Impairment of Regional Contractility and Left Ventricular Remodeling after Revascularized Acute Myocardial Infarction. Journal of Cardiovascular Emergencies 2015;1(1):35-41 DOI: 1515/jce-2015-006

75. Ciprian Blendea, Imre Benedek, Monica Chitu. „Treatment of Small Vessel Disease with the paclitaxel drug- eluting ballon” is the target lesion the culprit one. J International Cardiol, 2015,28:614. doi: 10.1111/joic.12256. FI 1,327

76. Cinteză M, Benedek I. Epicardial adipose tissue — a new biomarker of cardiovascular risk. Journal of Cardiovascular Emergencies. 2016;2:4-6. DOI: 10.1515/jce-2016-0001

77. Barcan A, Suciu Z, Benedek I. Response to Fragmented QRS Complex Predicts Contrast-Induced Nephropathy and In-Hospital Mortality After Primary Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction. Clin Cardiol. 2017 Nov;40(11):1174-1175. doi: 10.1002/clc.22778. FI 2,733

78. Szili Torok T, DE Vries LJ, Özcan EE, Hasdemir C, Kis Z, Kardos A, Géczy T, Kovacs I, Benedek I, Oosterwerff E, Hendriks AA, Khan M, Yap SC. Disappearance of Idiopathic Outflow Tract Premature Ventricular Contractions After Catheter Ablation of Overt Accessory Pathways. J Cardiovasc Electrophysiol. 2017;28(1):78-84. doi: 10.1111/jce.13098. FI 2,873

79. Orzan M, Rat N, Benedek I. Fractional flow reserve and visual assessment for moderate coronary artery stenosis. Kardiol Pol. 2017;75(11):1214-1215. doi: 10.5603/KP.2017.0223. FI 1,213

80. Benedek I. Atherosclerosis-Triggered Hypertension or Hypertension-Triggered Atherosclerosis? A Challenging Hypothesis. Journal of Cardiovascular Emergencies. 2017;3:5-8. DOI: 10.1515/jce-2017-0001.

81. Napp AE, Haase R, Laule M2 Schuetz GM, Rief M, Dreger H, Feuchtner G, Friedrich G, Špaček M, Suchánek V, Fuglsang Kofoed K, Engstroem T, Schroeder S, Drosch T, Gutberlet M, Woinke M, Maurovich-Horvat P, Merkely B, Donnelly P, Ball P, Dodd JD, Quinn M, Saba L, Porcu M, Francone M, Mancone M, Erglis A, Zvaigzne L, Jankauskas A, Sakalyte G, Harań T, Ilnicka-Suckiel M, Bettencourt N, Gama-Ribeiro V, Condrea S, Benedek I, Čemerlić Adjić N, Adjić O, Rodriguez-Palomares J, Garcia Del Blanco B, Roditi G, Berry C, Davis G, Thwaite E, Knuuti J, Pietilä M, Kępka C, Kruk M, Vidakovic R, Neskovic AN, Díez I, Lecumberri I, Geleijns J, Kubiak C, Strenge-Hesse A, Do TH, Frömel F, Gutiérrez-Ibarluzea I, Benguria-Arrate G, Keiding H, Katzer C, Müller-Nordhorn J, Rieckmann N, Walther M, Schlattmann P, Dewey M; DISCHARGE Trial Group. Computed tomography versus invasive coronary angiography: design and methods of the pragmatic randomised multicentre DISCHARGE trial. Eur Radiol. 2017 Jul;27(7):2957-2968. doi: 10.1007/s00330-016-4620-z. FI 4,027

82. Orzan M, Hodas R, Dobra M, Rat N, Chitu M, Benedek I. Transluminal Contrast Attenuation Gradient Is Associated with Coronary Plaque Vulnerability — a Computed Tomography Angiography-based Study. Journal of Cardiovascular Emergencies. 2017;3(3):121-127. DOI: 10.1515/jce-2017-0016.

83. Mirabela Morariu, Emese Márton, András Mester, Mihaela Rațiu, Imre Benedek. Association between Acute Inflammatory Response and Infarct Size in STEMI Patients Undergoing Primary PCI. Journal of Cardiovascular Emergencies 2018;4(3):140-146. DOI: 10.2478/jce-2018-0017.

84. Benedek I. A New Definition of Acute Myocardial Infarction - Changing Perspectives in Acute Cardiac Care. Journal of Cardiovascular Emergencies. 2018;4(4):167-169. DOI: 10.2478/jce-2018-0024.

85. Florin Ferent I, Mester A, Hlinomaz O, Groch L, Rezek M, Sitar J, Semenka J, Novak M, Benedek I. Intracoronary Imaging for Assessment of Vascular Healing and Stent Follow-up in Bioresorbable Vascular Scaffolds. Curr Med Imaging Rev. 2020;16(2):123-134. doi: 10.2174/1573405614666180604093621. FI 0,812

87. Benedek I. For the Good Times. JOURNAL OF CARDIOVASCULAR EMERGENCIES. 2020‏; 6(3): ‏ ‏ 48-49 DOI: 10.2478/jce-2020-0015

88. Rat N, Muntean I, Opincariu D, Gozar L, Togănel R, Chițu M. Cardiovascular Imaging for Guiding Interventional Therapy in Structural Heart Diseases. Curr Med Imaging Rev. 2020;16(2):111-122. doi: 10.2174/1573405614666180612081736. FI 0,812

89. Marius Orzan, Mihaela Dobra, Monica Chițu. A Comparative Preliminary Study on CT Contrast Attenuation Gradient Versus Invasive FFR in Patients with Unstable Angina. Journal of Cardiovascular Emergencies 2017;3(2):72-78. DOI: 10.1515/jce-2017-0012

90. Stănescu A, Suciu Zs, Rat N, Morariu M, Chițu M. CT-based assessment of myocardial bridging in patients with acute chest pain and no atherosclerotic etiology ct-based assessment of myocardial bridging in patients with acute chest pain and no atherosclerotic etiology. Journal of Cardiovascular Emergencies. 2016;2:71-75. DOI: 10.1515/jce-2016-0011

91. Sitar J, Groch L, Hlinomaz O, Rezek M, Seménka J. How to treat spontaneous coronary artery dissection. Journal of Cardiovascular Emergencies. 2015;1:27-31. DOI: 10.1515/jce-2016-0005

92. Bajka B, Benedek E, Stănescu A, Rapolti E, Chițu M, Kovács I. Treatment difficulties in high risk pulmonary embolism. A case report. Journal of Cardiovascular Emergencies. 2015;1:37-42. DOI: 10.1515/jce-2016-0007

93. Bărcan A, Chițu M, Benedek E, Rat N, Korodi S, Morariu M, Kovacs I. Predictors of Mortality in Patients with ST-Segment Elevation Acute Myocardial Infarction and Resuscitated Out-of-Hospital Cardiac Arrest. J Crit Care Med (Targu Mures). 2016 Feb 9;2(1):22-29. doi: 10.1515/jccm-2016-0001.

94. Barcan A, Kovacs I, Blendea C, Orzan M, Chitu M. Factors associated with in-hospital mortality in patients with acute coronary syndrome. Journal of Cardiovascular Emergencies. 2015;1:68-74. DOI: 10.1515/jce-2015-0010

95. Blendea C, Kovács I, Bărcan A, Nyulas T, Chițu M. The value of angio CT multislice for pre-operative assessment and prediction of post PCI successful intervention in acute coronary syndromes associated by left main disease. Journal of Cardiovascular Emergencies. 2015;1:29-34. DOI: 10.1515/jce-2015-0005

96. Kis Z, Hendriks AA, Muka T, Bramer WM, Kovacs I, Szili-Torok T. The Role of Atrial Fibrosis Detected by Delayed - Enhancement MRI in Atrial Fibrillation Ablation. Curr Med Imaging Rev. 2020;16(2):135-144. doi: 10.2174/1573405614666180806130327. FI 0,812

97. Kovács I, Condrea S, Rodean I, Cernica D. Multiple Mediastinal Arteriovenous Fistulas in a Patient with Myocardial Ischemia Symptoms and Tachy-Brady Arrhythmias. Journal of Cardiovascular Emergencies. 2017;3:44-47. DOI: 10.1515/jce-2017-0007.

98. Bajka B, Orzan M, Jakó B, Kovács I. Distance-related differences in critical times, protocol activation and mortality in a regional STEMI network. Journal of Cardiovascular Emergencies. 2016;2:122-128. DOI: 10.1515/jce-2016-0019

99. Benedek E, Stănescu A, Orzan M, Rat N, Kovács I, Suciu Zs. Characteristics of neoatherosclerosis within implanted coronary stents in patients with acute coronary syndromes. Journal of Cardiovascular Emergencies. 2015;1:19-26. DOI: 10.1515/jce-2016-0004

100. Țolescu C, Gerculy R, Libenciuc C, Kovacs I. Differential Diagnosis of Myocardial Injury in the SARS-CoV-2 Era – Myocarditis Versus Acute Coronary Syndrome. Journal of Cardiovascular Emergencies 2020;6(4):98-103. DOI: 10.2478/jce-2020-0013

101. Opincariu D, Chițu M, Rat N, Benedek I. Integrated ST segment elevation scores and in-hospital mortality in STEMI patients undergoing primary PCI. Journal of Cardiovascular Emergencies. 2016;2:114-121. DOI: 10.1515/jce-2016-0018

Lucrări publicate in extenso vizibile în ISI Web of Science ca Study Investigators

1. Ellis SG, Tendera M, de Belder MA, van Boven AJ, Widimsky P, Janssens L, Andersen HR, Betriu A, Savonitto S, Adamus J, Peruga JZ, Kosmider M, Katz O, Neunteufl T, Jorgova J, Dorobantu M, Grinfeld L, Armstrong P, Brodie BR, Herrmann HC, Montalescot G, Neumann FJ, Effron MB, Barnathan ES, Topol EJ; FINESSE Investigators. Facilitated PCI in patients with ST-elevation myocardial infarction. N Engl J Med. 2008 May 22;358(21):2205-17. doi: 10.1056/NEJMoa0706816. FI 50,017

2. Mehta SR, Granger CB, Boden WE, Steg PG, Bassand JP, Faxon DP, Afzal R, Chrolavicius S, Jolly SS, Widimsky P, Avezum A, Rupprecht HJ, Zhu J, Col J, Natarajan MK, Horsman C, Fox KA, Yusuf S; TIMACS Investigators. Early versus delayed invasive intervention in acute coronary syndromes. N Engl J Med. 2009 May 21;360(21):2165-75. doi: 10.1056/NEJMoa0807986. FI 47,050

3. Mehta SR, Tanguay JF, Eikelboom JW, Jolly SS, Joyner CD, Granger CB, Faxon DP, Rupprecht HJ, Budaj A, Avezum A, Widimsky P, Steg PG, Bassand JP, Montalescot G, Macaya C, Di Pasquale G, Niemela K, Ajani AE, White HD, Chrolavicius S, Gao P, Fox KA, Yusuf S; CURRENT-OASIS 7 trial investigators. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010 Oct 9;376(9748):1233-43. doi: 10.1016/S0140-6736(10)61088-4. FI 33,633

4. CURRENT-OASIS 7 Investigators, Mehta SR, Bassand JP, Chrolavicius S, Diaz R, Eikelboom JW, Fox KA, Granger CB, Jolly S, Joyner CD, Rupprecht HJ, Widimsky P, Afzal R, Pogue J, Yusuf S. Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med. 2010 Sep 2;363(10):930-42. doi: 10.1056/NEJMoa0909475. FI 53,486

5. Merkely B, Kautzner J, Milasinovic G, Hatala R, Taborsky M, Lubinski A, Dan GA, Zima E, Milicic D, Auricchio A, Camm AJ, Wolpert C, Vardas P; EHRA Summit 2010. Summary statement: EHRA summit 2010 with the participation of Central-Eastern European countries: 'ICD for Life' Initiative--fighting against sudden cardiac death in emerging economies. Europace. 2011 Aug;13(8):1209-10. doi: 10.1093/europace/eur158. FI 1,980

6. Granger CB, Alexander JH, McMurray JJ, Lopes RD, Hylek EM, Hanna M, Al-Khalidi HR, Ansell J, Atar D, Avezum A, Bahit MC, Diaz R, Easton JD, Ezekowitz JA, Flaker G, Garcia D, Geraldes M, Gersh BJ, Golitsyn S, Goto S, Hermosillo AG, Hohnloser SH, Horowitz J, Mohan P, Jansky P, Lewis BS, Lopez-Sendon JL, Pais P, Parkhomenko A, Verheugt FW, Zhu J, Wallentin L; ARISTOTLE Committees and Investigators. Apixaban versus warfarin in patients with atrial fibrillation. N Engl J Med. 2011 Sep 15;365(11):981-92. doi: 10.1056/NEJMoa1107039. FI 53,298

7. Steg PG, Mehta SR, Jukema JW, Lip GY, Gibson CM, Kovar F, Kala P, Garcia-Hernandez A, Renfurm RW, Granger CB; RUBY-1 Investigators. RUBY-1: a randomized, double-blind, placebo-controlled trial of the safety and tolerability of the novel oral factor Xa inhibitor darexaban (YM150) following acute coronary syndrome. Eur Heart J. 2011 Oct;32(20):2541-54. doi: 10.1093/eurheartj/ehr334. FI 10,478

8. Mega JL, Braunwald E, Wiviott SD, Bassand JP, Bhatt DL, Bode C, Burton P, Cohen M, Cook-Bruns N, Fox KA, Goto S, Murphy SA, Plotnikov AN, Schneider D, Sun X, Verheugt FW, Gibson CM; ATLAS ACS 2–TIMI 51 Investigators. Rivaroxaban in patients with a recent acute coronary syndrome. N Engl J Med. 2012 Jan 5;366(1):9-19. doi: 10.1056/NEJMoa1112277. FI 51,658

9. Neutel JM, Mancia G, Black HR, Dahlöf B, Defeo H, Ley L, Vinisko R; TEAMSTA Severe HTN Study Investigators. Single-pill combination of telmisartan/amlodipine in patients with severe hypertension: results from the TEAMSTA severe HTN study. J Clin Hypertens (Greenwich). 2012 Apr;14(4):206-15. doi: 10.1111/j.1751-7176.2012.00595.x. FI 2,958

10. Easton JD, Lopes RD, Bahit MC, Wojdyla DM, Granger CB, Wallentin L, Alings M, Goto S, Lewis BS, Rosenqvist M, Hanna M, Mohan P, Alexander JH, Diener HC; ARISTOTLE Committees and Investigators. Apixaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of the ARISTOTLE trial.
Lancet Neurol. 2012 Jun;11(6):503-11. doi: 10.1016/S1474-4422(12)70092-3. FI 23,917

11. STABILITY Investigators, White HD, Held C, Stewart R, Tarka E, Brown R, Davies RY, Budaj A, Harrington RA, Steg PG, Ardissino D, Armstrong PW, Avezum A, Aylward PE, Bryce A, Chen H, Chen MF, Corbalan R, Dalby AJ, Danchin N, De Winter RJ, Denchev S, Diaz R, Elisaf M, Flather MD, Goudev AR, Granger CB, Grinfeld L, Hochman JS, Husted S, Kim HS, Koenig W, Linhart A, Lonn E, López-Sendón J, Manolis AJ, Mohler ER 3rd, Nicolau JC, Pais P, Parkhomenko A, Pedersen TR, Pella D, Ramos-Corrales MA, Ruda M, Sereg M, Siddique S, Sinnaeve P, Smith P, Sritara P, Swart HP, Sy RG, Teramoto T, Tse HF, Watson D, Weaver WD, Weiss R, Viigimaa M, Vinereanu D, Zhu J, Cannon CP, Wallentin L. Darapladib for preventing ischemic events in stable coronary heart disease. N Engl J Med. 2014 May 1;370(18):1702-11. doi: 10.1056/NEJMoa1315878. FI 55,873

12. Lincoff AM, Tardif JC, Schwartz GG, Nicholls SJ, Rydén L, Neal B, Malmberg K, Wedel H, Buse JB, Henry RR, Weichert A, Cannata R, Svensson A, Volz D, Grobbee DE; AleCardio Investigators. Effect of aleglitazar on cardiovascular outcomes after acute coronary syndrome in patients with type 2 diabetes mellitus: the AleCardio randomized clinical trial. JAMA. 2014 Apr 16;311(15):1515-25. doi: 10.1001/jama.2014.3321. FI 35,289

13. O'Donoghue ML, Braunwald E, White HD, Lukas MA, Tarka E, Steg PG, Hochman JS, Bode C, Maggioni AP, Im K, Shannon JB, Davies RY, Murphy SA, Crugnale SE, Wiviott SD, Bonaca MP, Watson DF, Weaver WD, Serruys PW, Cannon CP; SOLID-TIMI 52 Investigators, Steen DL. Effect of darapladib on major coronary events after an acute coronary syndrome: the SOLID-TIMI 52 randomized clinical trial. JAMA. 2014 Sep 10;312(10):1006-15. doi: 10.1001/jama.2014.11061. FI 35,289

14. Bonaca MP, Bhatt DL, Cohen M, Steg PG, Storey RF, Jensen EC, Magnani G, Bansilal S, Fish MP, Im K, Bengtsson O, Oude Ophuis T, Budaj A, Theroux P, Ruda M, Hamm C, Goto S, Spinar J, Nicolau JC, Kiss RG, Murphy SA, Wiviott SD, Held P, Braunwald E, Sabatine MS; PEGASUS-TIMI 54 Steering Committee and Investigators. Long-term use of ticagrelor in patients with prior myocardial infarction. N Engl J Med. 2015 May 7;372(19):1791-800. doi: 10.1056/NEJMoa1500857. FI 59,558

15. Gyöngyösi M, Wojakowski W, Navarese EP, Moye LÀ; ACCRUE Investigators. Meta-Analyses of Human Cell-Based Cardiac Regeneration Therapies: Controversies in Meta-Analyses Results on Cardiac Cell-Based Regenerative Studies. Circ Res. 2016 Apr 15;118(8):1254-63. doi: 10.1161/CIRCRESAHA.115.307347. FI 11,551

16. Hiatt WR, Fowkes FG, Heizer G, Berger JS, Baumgartner I, Held P, Katona BG, Mahaffey KW, Norgren L, Jones WS, Blomster J, Millegård M, Reist C, Patel MR; EUCLID Trial Steering Committee and Investigators. Ticagrelor versus Clopidogrel in Symptomatic Peripheral Artery Disease. N Engl J Med. 2017 Jan 5;376(1):32-40. doi: 10.1056/NEJMoa1611688. FI79,260

17. Eikelboom JW, Connolly SJ, Bosch J, Dagenais GR, Hart RG, Shestakovska O, Diaz R, Alings M, Lonn EM, Anand SS, Widimsky P, Hori M, Avezum A, Piegas LS, Branch KRH, Probstfield J, Bhatt DL, Zhu J, Liang Y, Maggioni AP, Lopez-Jaramillo P, O'Donnell M, Kakkar AK, Fox KAA, Parkhomenko AN, Ertl G, Störk S, Keltai M, Ryden L, Pogosova N, Dans AL, Lanas F, Commerford PJ, Torp-Pedersen C, Guzik TJ, Verhamme PB, Vinereanu D, Kim JH, Tonkin AM, Lewis BS, Felix C, Yusoff K, Steg PG, Metsarinne KP, Cook Bruns N, Misselwitz F, Chen E, Leong D, Yusuf S; COMPASS Investigators. Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease. N Engl J Med. 2017 Oct 5;377(14):1319-1330. doi: 10.1056/NEJMoa1709118. FI 79,260

18. Ridker PM, Everett BM, Thuren T, MacFadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ; CANTOS Trial Group. Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease. N Engl J Med. 2017 Sep 21;377(12):1119-1131. doi: 10.1056/NEJMoa1707914. FI 79,260

19. Connolly SJ, Eikelboom JW, Bosch J, Dagenais G, Dyal L, Lanas F, Metsarinne K, O'Donnell M, Dans AL, Ha JW, Parkhomenko AN, Avezum AA, Lonn E, Lisheng L, Torp-Pedersen C, Widimsky P, Maggioni AP, Felix C, Keltai K, Hori M, Yusoff K, Guzik TJ, Bhatt DL, Branch KRH, Cook Bruns N, Berkowitz SD, Anand SS, Varigos JD, Fox KAA, Yusuf S; COMPASS investigators. Rivaroxaban with or without aspirin in patients with stable coronary artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet. 2018 Jan 20;391(10117):205-218. doi: 10.1016/S0140-6736(17)32458-3. FI 59,102

20. Anand SS, Bosch J, Eikelboom JW, Connolly SJ, Diaz R, Widimsky P, Aboyans V, Alings M, Kakkar AK, Keltai K, Maggioni AP, Lewis BS, Störk S, Zhu J, Lopez-Jaramillo P, O'Donnell M, Commerford PJ, Vinereanu D, Pogosova N, Ryden L, Fox KAA, Bhatt DL, Misselwitz F, Varigos JD, Vanassche T, Avezum AA, Chen E, Branch K, Leong DP, Bangdiwala SI, Hart RG, Yusuf S; COMPASS Investigators. Rivaroxaban with or without aspirin in patients with stable peripheral or carotid artery disease: an international, randomised, double-blind, placebo-controlled trial. Lancet. 2018 Jan 20;391(10117):219-229. doi: 10.1016/S0140-6736(17)32409-1. FI 59,102

21. Zannad F, Anker SD, Byra WM, Cleland JGF, Fu M, Gheorghiade M, Lam CSP, Mehra MR, Neaton JD, Nessel CC, Spiro TE, van Veldhuisen DJ, Greenberg B; COMMANDER HF Investigators. Rivaroxaban in Patients with Heart Failure, Sinus Rhythm, and Coronary Disease. N Engl J Med. 2018 Oct 4;379(14):1332-1342. doi: 10.1056/NEJMoa1808848. FI 70,670

22. Metra M, Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Voors AA, Adams KF, Anker SD, Arias-Mendoza A, Avendaño P, Bacal F, Böhm M, Bortman G, Cleland JGF, Cohen-Solal A, Crespo-Leiro MG, Dorobantu M, Echeverría LE, Ferrari R, Goland S, Goncalvesová E, Goudev A, Køber L, Lema-Osores J, Levy PD, McDonald K, Manga P, Merkely B, Mueller C, Pieske B, Silva-Cardoso J, Špinar J, Squire I, Stępińska J, Van Mieghem W, von Lewinski D, Wikström G, Yilmaz MB, Hagner N, Holbro T, Hua TA, Sabarwal SV, Severin T, Szecsödy P, Gimpelewicz C; RELAX-AHF-2 Committees Investigators. N Engl J Med. 2019 Aug 22;381(8):716-726. doi: 10.1056/NEJMoa1801291. FI 70,670

3. EXPERIENȚĂ ÎN DERULARE CONTRACTE DE CERCETARE
1. Granturi de cercetare castigate prin competitie

1.1. Granturi de cercetare internationale câştigate prin competiţie
1) Diagnostic Imaging Strategies for Patients with Stable Chest Pain and Intermediate Risk of Coronary Artery Disease: Comparative Effectiveness Research of Existing Technologies
Acronim: DISCHARGE
Grant agrreement no. HEALTH-F2-2013-603266, program FP7-Health-2013-Innovation-1
Finanţator - Comisia Europeană, program FP7
Director de proiect/ Coordinator centru: Prof. Dr. Benedek Theodora
Valoarea proiectului (partener): 2.000.000 EUR / 150,000 EUR
Perioada de derulare: 2014-2016

2). Electronic Health Records for the Next Generation Medical Decision Support in Romanian and Bulgarian National Healthcare Systems
Proiect de cooperare bilaterala România – Bulgaria,
Acronim: NextGenElectroMedSupport
Nr. contract 461CB/23.10.2010
Coordonator Universitatea Petru Maior Tg.Mures
Director de proiect/ Coordinator centru: Prof. Dr. Benedek Theodora
Perioada de derulare: 2010-2012

1.2. Granturi de cercetare internationale câştigate prin competiţie
1) Hybrid Medical Complex Systems
Proiect de cooperare bilaterala România – Slovacia,
Acronim: ComplexMediSys
Nr. contract 476/07.03.2011
Coordonator Universitatea Petru Maior Tg.Mures
Director de proiect/ Coordinator centru: Prof. Dr. Benedek Theodora
Perioada de derulare: 2011-2012

1.3. Granturi si contracte nationale castigate prin competitie

1). Tehnologii tridimensionale de ultraSonografie computerizata si mapping intracardiac in diagnosticul si Tratamentul interventional bazat pe nanotehnologii a unor ARitmii
Acronim - STAR
Numar contract 42-131
Autoritatea Finanţatoare – Centrul Naţional de Management Programe, Ministerul Educaţiei şi Cercetării
Programul prin care se derulează proiectul - PNCD II
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Benedek Theodora
Valoarea proiectului – totala 2,000,000 RON, corespunzătoare UMF Tg.Mureş 1,640,000 RON
Perioada de derulare 2008-2011

2). Țesutul adipos epicardic, inflamația locală și vulnerabilitatea plăcilor ateromatoase-studiu imagistic computațional bazat pe inteligență artificfială. PN-III-P4-ID-PCE- 2020-286. UEFISCDI PROIECTE DE CERCETARE EXPLORATORIE (PCE 2020)
Director de proiect: Prof. Dr. Benedek Theodora

1.4. Granturi si contracte nationale castigate prin competitie

1) Platformă imagistică multimodală RMN/CT de înaltă performanţă, destinată aplicării medicinii computaționale, nanoparticulelor și imagisticii hibride în cercetarea bolilor aterotrombotice
Acronim – CARDIOIMAGE
Finanțator: Autoritatea Națională pentru Cercetare Științifică și Inovare
Proiect câștigător la competiți pentru infrastructuri private de cercetare 2015 – primul loc pe țară
Director de proiect: Prof. Dr. Benedek Imre
Valoare: 2.000.000 EURO

2) Translarea cercetărilor genomice de reconstrucţie intracardiacă şi tridimensională în diagnosticul şi tratamentul unor boli cardiace congenitale sau dobandite la adultul tânăr
Acronim – TRIDICO
Numar contract 72/2006
Autoritatea Finanţatoare – Academia de Ştiinţe Medicale, Ministerul Educaţiei şi Cercetării, prin programul CEEX 2006
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Benedek Imre
Valoarea proiectului – totala 1,500,000 RON, corespunzator UMF Tg.Mures 1.235.500 RON
Perioada de derulare 2006-2008

Adresa de web www.upm.ro/medicina/tridico

3) Translarea cercetărilor genomice în dezvoltarea de terapii inovative bazate pe transplantul de celule stem în bolile aterotrombotice – studiu integrat într-o experienţă europeană de cercetare de excelenţă
Acronim – TRANSCARDIOSTEM
Numar contract 172/2006
Autoritatea Finanţatoare – Academia de Ştiinţe Medicale, Ministerul Educaţiei şi Cercetării, prin programul CEEX 2006
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Benedek Imre
Valoarea proiectului – totala 1,500,000 RON, corespunzator UMF 1.220.488 RON
Perioada de derulare 2006-2008

Adresa de web www.upm.ro/medicina/transcardiosem

4) Implementarea suportului logistic in cadrul resecventionării genomice translationale a sindroamelor coronariene acute pe o populatie tintă de 1 milion locuitori – LOGECA
Acronim – LOGECA
Numar contract 171/2006
Autoritatea Finanţatoare – Academia de Ştiinţe Medicale, Ministerul Educaţiei şi Cercetării, prin programul CEEX 2006
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Toganel Rodica
Valoarea proiectului – totala 1,500,000 RON, corespunzator UMF 995.000 RON
Perioada de derulare 2006-2008

Adresa de web www.upm.ro/medicina/logeca

5) Dezvoltarea parteneriatului internaţional privind transplantul de celule stem în Sindroamele COronariene Acute în cadrul unei Reţele europene de cercetare de Excelenţă
Acronim – COREX
Numar contract 212/2006
Autoritatea Finanţatoare – Ministerul Educaţiei şi Cercetării, prin programul CEEX 2006
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Benedek Imre
Valoarea proiectului – totala 200,000 RON, corespunzatoar UMF 99.250 RON
Perioada de derulare 2006-2008

Adresa de web corex.8k.ro

6) Translarea cercetarilor hemoreobiologice privind interactiunea laser-plasma in terapii innovative adresate placii aterosclerotice coronariene, intimei vasculare si biomaterialelor implantate.
Acronim – LASCOR
Numar contract 41-069/2007
Autoritatea Finanţatoare – CNMP - PNCD II, Programul parteneriate
Director de proiect: Prof. Dr. Benedek Imre
Valoarea proiectului – totala 2,000,000 RON, corespunzator UMF TG.Mures 1.273.774 RON
Perioada de derulare 2007-2010

Adresa de web www.upm.ro/medicina/lascor

7) Translarea cercetarilor genomice referitoare la etiologia MAlformatiilor cardiace congenitale in Metode inovative de screening, preventie prenatala, diagnostic genetic si Imagistica tridimensionala
Acronim – MAMI
Numar contract 41-042/2007
Autoritatea Finanţatoare – CNMP - PNCD II, Programul parteneriate
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Toganel Rodica
Valoarea proiectului – totala 2,000,000 RON, corespunzator UMF Tg.Mures 1.707.500 RON
Perioada de derulare 2007-2010

Adresa de web www.upm.ro/medicina/mami

8) Evaluarea 3D computerizata a viabilitatii miocardice, translata in metode inovative de tratament medicamentos, interventional si prin transplant de celule stem in cardiomiopatia dilatativa ischemica
Numar contract 438/2007
Autoritatea Finanţatoare – PNCD II, Programul Idei
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Benedek Imre
Valoarea proiectului – totala 1,000,000 RON, corespunzatoare UMF Tg.Mures 1.000.000 RON
Perioada de derulare 2007-2009

Adresa de web idei.8k.ro

9) Laborator de EXcelenţă în Electrofiziologie şi Imagistică Cardiacă Tridimensională ca referinţă regională a standardelor europene. - LEXIC
Numar contract 350/2007
Autoritatea Finanţatoare – Ministerul Educatiei si Cercetarii, Autoritatea Nationala de Cercetare Stiintifica – Program IMPACT
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Benedek Imre
Valoarea proiectului – totala 100,000 RON, corespunzatoare UMF 100.000 RON
Perioada de derulare 2007

10) Centru de diagnostic precoce, tratament, educare şi formare profesională în afecţiunile cardiace la copil - DIACORD
Numar contract 349/2007
Autoritatea Finanţatoare – Ministerul Educatiei si Cercetarii, Autoritatea Nationala de Cercetare Stiintifica – Program IMPACT
Universitatea contractantă – UMF Tg.Mureş
Director de proiect: Prof. Dr. Toganel Rodica
Valoarea proiectului – totala 100,000 RON, corespunzatoare UMF Tg.Mures 100.000 RON
Perioada de derulare - 2007

Premii internaționale
- "Best Manuscript Award" al revistei Circulation Research (factor de impact 11.08), November 8, 2015, pentru Meta-analiza ACCRUE
- Prof. Dr. Benedek Theodora- Best Poster presentation – Acute Cardiac Care congress, martie 2019, Malaga (Spania)

TEME SI DIRECTII DE CERCETARE

1. Corelatii intre statusul nutritional si functia VS in infarctul miocardic
2. Corelatii intre statusul nutritional si evolutia postinfarct miocardic (studiu follow-up)
3. Biomarkeri inflamatori si functia ventriculara in Infarctul miocardic acut, evaluata prin eco speckle tracking
4. Corelatia dintre biomarkerii inflamatori si remodelarea postinfarct miocardic
5. Corelatia dintre raspunsul inflamator postinfarct miocardic si extensia miocardului necrozat - studiu RMN
6. Corelatii intre biomarkerii serici si imagistici care exprima functia VS si tesutul adipos epicardic la pacientii cu infarct miocardic acut
7. Corelatia dintre boala parodontala si boala cardiovasculara.
8. Corelatia dintre boala parodontala si markerii de vulnerabilitate a placilor ateromatoase
9. Tehnologii de printare 3D bazate pe imagistica in ghidarea terapiilor interventionale
10. Corelatia dintre excentricitatea placilor coronariene si gradul de vulnerabilitate
11. Tesutul adipos periaterom si markerii de vulnerabilitate in angina instabila
12. Corelatii intre FFR-CT si gradientul de contrast transluminal CT
13. Corelatii intre FFR-CT si markerii de vulnerabilitate a placilor ateromatoase
14. Corelatii intre FFR-CT si tesutul epicardic regional la pacientii cu boala coronariana
15. Evaluarea bazata pe nanoparticule a placii ateromatoase instabile la animale de laborator
16. Corelatii intre shear stressul coronarian si markerii de vulnerabilitate a placilor ateromatoase
17. Corelatii intre gradientul de shear stress coronarian si semnificatia functionala a stenozelor coronariene
18. Markerii predictivi imagistici şi inflamatorii in prevenirea recurentelor fibrilatiei atriale dupa izolarea venelor pulmonare prin mapping electroanatomic
19. Markerii predictivi imagistici şi inflamatorii in prevenirea recurentelor fibrilatiei atriale
20. Markeri imagistici pentru predictia aparitiei FiA in perioada postinfarct
21. Cercetarea factorilor imagistici de remodelare al atriului stang si tromboza intracavitara in fibrilatia atriala
22. Corelatii intre markerii inflamatori si riscul de aritmii postinfarct
23. Cercetarea modelelor de cost-eficienta in explorarea imagistica a afectiunilor coronariene
24. Cercetarea modelelos de cost-eficienta in urmarirea postinfarct
25. Scorul de calciu iliac ca marker predictiv al severitatii arteriopatiei cronice obliterante
26. Rolul tesutului adipos perivascular in boala arteriala obstructiva periferica
27. Rolul tesutului adipos perivascular din jurul arterei renale in HTA
28. Corelatii intre metodele de reabilitare, raspunsul inflamator si evolutia postinfarct miocardic
29. Biomarkeri serici si imagistici in insuficienta cardiaca
30. Corelatia dintre grosimea intima-medie si markerii imagistici si inflamatori in sindroamele coronariene acute
31. Corelatia dintre circumferinta gatului si factorii de risc cardiovasculari
32. Factori predictivi pentru mortalitate in stopul cardiac resuscitat
33. Studiu imagistic intracoronarian la pacientii cu sindrom coronarian acut si coronare angiografic normale
34. Factori predictivi pentru fenomenul de no reflow post PCI
35. Caracterizarea perfuziei miocardice la CT la pacientii cu placi coronariene vulnerabile
36. Factori predictivi pentru dinamica raspunsului inflamator postinfarct
37. Studiul nivelului seric al moleculelor de adeziune la pacientii cu placi coronariene instabile
38. Factori predictivi pentru mortalitate in embolia pulmonara
39. Rolul tratamentului bazat pe impregnarea placilor vulnerabile cu nanoparticule antiproliferative in vivo
40. Factori asociati cu infarctul NSTEMI cu coronare normale