UMFST - Universitatea de Medicină, Farmacie, Științe și Tehnologie din Târgu Mureș
 

Cercetare

Teme și direcții de cercetare

1. Evaluarea factorilor de risc cardiovascular in sindroame coronariene si cerebrovasculare; evaluarea factorilor genetici de risc CV; mutatii ale genelor LDLR, APOB, PCSK9, APOE

2. Determinarea rezistentei la antiagregante plachetare – teste functionale si moleculare (polimorfisme CYP2C19)

3. Determinarea mutatiilor F V Leiden si proF II (G20210A)

4. Determinare fenotipului HLA-B27 prin citometrie in flux si test molecular

5. Determinarea genotipurilor DQ2/DQ8 pentru boala celiacă

6. Determinarea genotipurilor caracteristice pentru persistenta lactazei

7. Teste functionale leucocitare – chemotactism, generarea speciilor reactive ale oxigenului

8. Imunofenotipari proliferari maligne hematologice prin citometrie in flux

9. Determinarea biomarkerilor inflamatori, de reconstructie si regenerare in AVC

10. Diagnosticul si monitorizarea statusului imun celular si umoral la imunodeprimati (limfograma calitativa si cantitativa) prin citometrie in flux si nefelometrie (C1INH, suclase IgG1-4, IgE)

11. Determinarea incarcaturii virale HIV ARN

12. Determinarea genotipurilor oncogene HPV

13. Parametrii calitatii in laboratorul de analize medicale

Articole reprezentative ale disciplinei publicate în ultimii ani in reviste cotate/indexate ISI

1. Dobreanu Minodora, Oprea Oana Roxana. Laboratory medicine in the era of precision medicine – dream or reality?.Rev Romana Med Lab. 2019;27(2):115-24. DOI:10.2478/rrlm-2019-0025

2. Horváth E, Huțanu A, Orădan A, Chiriac L, Muntean DL, Nagy EE, Dobreanu M. N-3 polyunsaturated fatty acids induce granulopoiesis and early monocyte polarization in the bone marrow of a tMCAO rat model. Rev Romana Med Lab. 2019;27(1):51-61. DOI:10.2478/rrlm-2019-0004, IF 2017=0.400

3. Floredana-Laura Șular, Edit Szekely, Violeta Corina Cristea, Minodora Dobreanu. Invasive Fungal Infection in Romania: Changing Incidence and Epidemiology During Six Years of Surveillance in a Tertiary Hospital. Mycopathologia. DOI :10.1007/s11046-018-0293-2 . IF 2017: 1.476

4. Floredana-Laura Șular, Mihaela Iancu, Manuela Cucerea, Elena Moldovan, Maria Livia Ognean, Minodora Dobreanu. Oxidative burst of neonatal and adult peripheral blood phagocytes confronting Escherichia coli and Candida albicans . Romanian Biotechnological Letters. DOI:10.26327/RBL2018.141. IF 2017: 0.321

5. Adina Huțanu, Emoke Horvath, Alex Orădan, Septimiu Voidăzan, Liviu Chiriac, Daniela Muntean, Minodora Dobreanu - Fish-oil preconditioning modulates plasma MCP-1 and TIMP-1 levels after experimental induced transient cerebral ischemia , Farmacia, 2018;66(4):602-208, https://doi.org/10.31925/farmacia.2018.4.7 , IF 2017=1.507

6. Adina HUȚANU, Mihaela IANCU, Rodica BĂLAȘA, Smaranda MAIER, Minodora DOBREANU - Predicting functional outcome of ischemic stroke patients in Romania based on plasma CRP, sTNFR-1, D-Dimers, NGAL and NSE measured using a biochip array, Acta Pharmacologica Sinica 2018: 39(7): 1228–1236, doi: 10.1038/aps.2018.26, IF 2017=3.223

7. Adina Huțanu, Smaranda Maier, Rodica Bălaşa, Oana Roxana Oprea, Ştefan Barbu, Septimiu Voidăzan, Minodora Dobreanu - Plasma phosphorylated neurofilament heavy chains as a potential marker for ischemic stroke patients. Rev Romana Med Lab. 2018;26(1):59-64. DOI:10.2478/rrlm-2018-0004, IF2017=0.4

8. Bernd Kaina , Alberto Izzotti , Jianzhen Xu , Markus Christmann , Alessandra Pulliero , Xing Zhao , Minodora Dobreanu , William W.Au Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy, International Journal of Hygiene and Environmental Health , Volume 221, Issue 7 , August 2018, Pages 993-1006, IF 2017=4.848

9. Cristina Oana Marginean, Lorena Elena Meliţ, Roxana-Cristina Mareş, Maria Oana Mărginean, Septimiu Voidăzan, Minodora Dobreanu - Clinical and biological correlations in celiac disease in children: the prospective single experience of a romanian tertiary center: A case-control study (Strobe-Compliant study) , Medicine, 2017;96(20):e6936, Published online 2017 May 19. doi: 10.1097/MD.0000000000006936 , IF2017=1.803

10. Alina Mărginean, Claudia Bănescu, Valeriu Moldovan, Alina Scridon, Mihai Mărginean, Rodica Bălaşa, Smaranda Maier, Mariana Ţăruşi and Minodora Dobreanu The Impact of CYP2C19 Loss-of-Function Polymorphisms, Clinical, and Demographic Variables on Platelet Response to Clopidogrel Evaluated Using Impedance Aggregometry , CLIN APPL THROMB HEMOST, 2017;23(3): 255-265, doi:10.1177/1076029616629211, http://cat.sagepub.com/content/early/2016/02/11/1076029616629211 , IF 2017= 1.852

11. A Orădan, A Huțanu, E Horváth, L Chiriac, M Dobreanu - Improved rat stroke model by intraluminal middle cerebral artery occlusion: a special emphasis on surgical technique Health Problems of Civilization.2017; 11 (3):200-210, DOI: https://doi.org/10.5114/hpc.2017.70008

12. Alina Mărginean, Claudia Bănescu, Alina Scridon, Minodora Dobreanu, Anti-platelet Therapy Resistance – Concept, Mechanisms and Platelet Function Tests in Intensive Care Facilities , JCCM 2016,2(1):6-15, DOI: 10.1515/jccm-2015-0021 , http://jccm.ro/anti-platelet-therapy-resistance-concept-mechanisms-and-platelet-function-tests-in-intensive-care-facilities/ , indexat ISI Thomson Reuters Scientific 2016

13. Carmen Rădulescu, Anca Bacârea, Adina Huțanu, Rozalia Gabor, Minodora Dobreanu - Placental Growth Factor, Soluble fms-Like Tyrosine Kinase 1, Soluble Endoglin, IL-6, and IL-16 as Biomarkers in Preeclampsia , Mediators of Inflammation Volume 2016, Article ID 3027363, https://www.hindawi.com/journals/mi/2016/3027363/abs/ , http://dx.doi.org/10.1155/2016/3027363 , FI 2016=3.238

14. Claudia Bănescu, Mihaela Iancu, Adrian P Trifa, Marcela Cândea, Erzsebet Benedek Lazar, Valeriu G Moldovan, Carmen Duicu, Florin Tripon, Andrei Crauciuc, Minodora Dobreanu, From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia , Oxidative Medicine and Cellular Longevity, 2016, Volume 2016, Article ID 2536705, 10 pages, http://dx.doi.org/10.1155/2016/2536705 , http://www.hindawi.com/journals/omcl/2016/2536705/ , FI 2015= 4.593

15. Remona E.David, Minodora Dobreanu – Pre-analytical Components of Risk in Four Branches of Clinical Laboratory in Romania – Prospective Study, Clin Lab 2016;62(6):1033-44, IF 2016=0.84

16. Septimiu Voidazan, Silviu-Horia Morariu, Monica Tarcea, Horațiu Moldovan, Minodora Dobreanu - Human Papilloma Virus (HPV) Infection and HPV Vaccination: Assessing the Level of Knowledge among Students of the University of Medicine and Pharmacy of Tirgu Mures, Romania , Acta Dermatovenerologica Croatica, 2016, 24(3):193-202, FI 2016=0.725

17. Adina Stoian, Claudia Bănescu, Rodica Ioana Bălaşa, Anca Moţăţăianu, Mircea Stoian, Valeriu G Moldovan, Septimiu Voidăzan, Minodora Dobreanu, Influence of GSTM1, GSTT1, and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Sensorimotor Peripheral Neuropathy Risk , Disease Markers 2015, Article ID 638693, 10 pages, ISSN 0278-0240, http://dx.doi.org/10.1155/2015/638693 http://www.hindawi.com/journals/dm/2015/638693/abs/ IF 2015=2.137

18. Amelia Tero-Vescan, S. Vancea, Adina Hutanu, Reka Borka-Balas, Minodora Dobreanu, Concordance and controversy in determining the omega-3 index in plasma and red blood cells membrane, Farmacia, 2015, 63(4):504-509, ISSN 0014-8237, IF 2015=1.3

19, Claudia Bănescu, Mihaela Iancu, Adrian P Trifa, Ioan Macarie, Delia Dima, Minodora Dobreanu, The methylenetetrahydrofolate reductase (MTHFR) 677 C> T polymorphism increases the risk of developing chronic myeloid leukemia—a case-control study , Tumor Biology , April 2015, 36( 4 ):3101-3107, ISSN - 1010-4283, IF 2015 =2.926.

20. Maria Dorobantu, Oana-Florentina Tautu, Roxana Darabont, Silviu Ghiorghe, Elisabeta Badila, Minca Dana, Minodora Dobreanu, Ilarie Baila, Marcin Rutkowski, Tomasz Zdrojewski, Objectives and methodology of Romanian SEPHAR II Survey . Project for comparing the prevalence and control of cardiovascular risk factors in two East-European countries: Romania and Poland, Arch Med Sci 2015;11(4):715–723, DOI:10.5114/aoms.2015.53290, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548029/ , IF 2015=1.812

Lucrări reprezentative prezentate la manifestări științifice naționale și internaționale in ultimii ani

1. Dobreanu M. Application of laboratory medicine technology for significant improvement in precision medicine, Romanian Journal of Laboratory Medicine, Suppl 3 vol.26, nr 4, Octombrie 2018, S11, 2284-5623, „First International Conference on Innovations in Population Health and Personalized Medicine”, Tg. Mureș 12-13 decembrie 2018, S11, http://rrml.ro/articole/2018/2018_4_supliment.pdf .

2. Hutanu Adina, Mihaela Iancu, Rodica Balasa, Smaranda Maier, Minodora Dobreanu: Clinical utility of a multiplex panel in a prediction of functional dependence in daily life activity after ischemic stroke Romanian Journal of Laboratory Medicine, Suppl 3 vol.26, nr 4, Octombrie 2018, S18, 2284-5623, „First International Conference on Innovations in Population Health and Personalized Medicine”, Tg. Mureș 12-13 decembrie 2018, S18, http://rrml.ro/articole/2018/2018_4_supliment.pdf

3. Moldovan V, Hadadi L, Demian L, Hutanu A, Serban R, Manescu B, Banescu C, Dobreanu M, Apolipoprotein E levels: a potential biomarker in statin treatment response , Romanian Journal of Laboratory Medicine, Suppl 3 vol.26, nr 4, Octombrie 2018, S12, 2284-5623, „First International Conference on Innovations in Population Health and Personalized Medicine”, Tg. Mureș 12-13 decembrie 2018, S12, http://rrml.ro/articole/2018/2018_4_supliment.pdf

4. George-Valeriu Moldovan, Claudia Bănescu, Laszlo Hadadi, Răzvan Serban, Irina Pintilie, Minodora Dobreanu - APOB P.ARG3527GLN MUTATION CAUSES FAMILIAL HYPERCHOLESTEROLEMIA, 2nd Congress of RALM, Bucuresti 9-12 mai 2018, in Rev Romana Med Lab, 2018, Supl 26 (2), p.S86-S87. http://rrml.ro/articole/2018/2018_2_supliment.pdf

5. Huțanu Adina, Balasa Rodica; Barbu Stefan; Maier Smaranda; Tero-Vescan Amelia; Oprea Oana; Dobreanu Minodora - DIFFERENT PATTERN OF FATTY ACIDS PROFILE IN ERYTHROCYTE MEMBRANES AND PLASMA OF ISCHAEMIC STROKE PATIENTS COMPARED TO HEALTHY CONTROLS, 2nd Congress of RALM, Bucuresti 9-12 mai 2018, in Rev Romana Med Lab, 2018, Supl 26 (2), p.S100-S101. http://rrml.ro/articole/2018/2018_2_supliment.pdf

6. Mihaela ZAHARIA, Oana OPREA, Stefan BARBU, Minodora DOBREANU, COMPARABILITY OF RESULTS FOR CBC BETWEEN CELL-DYN RUBY AND SYSMEX XT-4000i, 2nd Conference of the Romanian Association of Laboratory Medicine with international Participation, Timisoara 10-13 May 2017, in Rev Romana Med Lab, 2017, Supl 25 (2), p.S131-S132.

7. Stefan BARBU, Oana OPREA, Elena BINZARI, Minodora DOBREANU, STUDY ON COMPARABILITY OF COAGULATION TESTS RESULTS BETWEEN SYSMEX CS 2000I AND GRIFOLS Q AUTOMATED SYSTEMS, 2nd Conference of the Romanian Association of Laboratory Medicine with international Participation, Timisoara 10-13 May 2017, in Rev Romana Med Lab, 2017, Supl 25 (2), p.S129-S130.

8. Minodora Dobreanu, Valeriu George Moldovan, Adina Huțanu, Laszlo Hadadi, Razvan Serban, Claudia Bănescu, Development of a predictive multiplex microarray model usable as a tool for determination of coronary artery disease genetic risk in the Romanian population, 2nd Conference of the Romanian Association of Laboratory Medicine with international Participation, Timisoara 10-13 May 2017, in Rev Romana Med Lab, 2017, Supl 25 (2), p.S90-S91, http://rrml.ro/articole/2017/2017_1_supliment.pdf .

9. Valeriu Moldovan, Claudia Bănescu, Elena Moldovan, Răzvan Șerban, Minodora Dobreanu, FAMILIAL HYPERCHOLESTEROLAEMIA DIAGNOSIS: A CHALLENGE, 2nd Conference of the Romanian Association of Laboratory Medicine with international Participation, Timisoara 10-13 May 2017, in Rev Romana Med Lab, 2017, Supl 25 (2), p.S49-S50.

10. Remona Eliza David, Minodora Dobreanu, THE USE OF QUALITY INDICATORS AND THE INFLUENCE ON QUALITY COSTS IN A CLINICAL LABORATORY, 2nd Conference of the Romanian Association of Laboratory Medicine with international Participation, Timisoara 10-13 May 2017, in Rev Romana Med Lab, 2017, Supl 25 (2), p.S22-S23.

11. Floredana-Laura Șular, Minodora Dobreanu, Method verification and validation of an IVD flow cytometry method for oxidative burst quantification generated by C. albicans in mononuclear cells , 1st Conference of the Romanian Association of Laboratory Medicine with international Participation, Cluj Napoca 18-21 May 2016, in Rev Romana Med Lab, 2016, Supl 24 (1), p.S134-S135, IF 2016 = 0.325

12. Remona Eliza David, Minodora Dobreanu, Development and use of Quality Indicators in a branch of a nationaL clinical laboratory, 1st conference of the Romanian Association of Laboratory Medicine with international Participation, Cluj Napoca 18-21 May 2016, in Rev Romana Med Lab, 2016, Supl 24 (1), p.S127-S128, IF 2016 = 0.325

13. Floredana-Laura Șular, Elena Moldovan, Manuela Cucerea, Minodora Dobreanu, Are respiratory burst alterations in Peripheral Blood Mononuclear Cells a cause for increased susceptibility to infections in neonates?, 1st conference of the Romanian Association of Laboratory Medicine with international Participation, Cluj Napoca 18-21 May 2016, in Rev Romana Med Lab, 2016, Supl 24 (1), p.S120-S122, IF 2016 = 0.325

14. Alina Mărginean, Claudia Bănescu, Valeriu Moldovan, Alina Scridon, Mihai Mărginean, Rodica Bălasa, Smaranda Maier, Mariana Ţărusi, Minodora Dobreanu, The impact of CYP2C19 polymorphisms, clinical and laboratory variables on platelet response to antiplatelet agents, 1st conference of the Romanian Association of Laboratory Medicine with international Participation, Cluj Napoca 18-21 May 2016, in Rev Romana Med Lab, 2016, Supl 24 (1), p.S61-S62, IF 2016 = 0.325

15. Claudia Bănescu, Valeriu G Moldovan, Florin Tripon, Andrei Crauciuc, Carmen Duicu, Alina Boglis, Minodora Dobreanu, Single Nucleotide Polymorphisms XPC Lys939Gln and XPG Asp1104His in Romanian Patients with Chronic Myeloid Leukemia , 1st conference of the Romanian Association of Laboratory Medicine with international Participation, Cluj Napoca 18-21 May 2016, in Rev Romana Med Lab, 2016, Supl 24 (1), p.S57-S58, IF 2016 = 0.325

16. Oana Oprea, Adina Hutanu, Ștefan Barbu, Minodora Dobreanu, The influence of sampling technique on concentrations determined with the TSH screening method on newborns , 1st conference of the Romanian Association of Laboratory Medicine with international Participation, Cluj Napoca 18-21 May 2016, in Rev Romana Med Lab, 2016, Supl 24 (1), p.S32-S33, IF 2016 = 0.325

17. Minodora Dobreanu, Floredana Şular, Adrian Man, Ethical considerations in scientific Papers – experience of RJLabM Editorial Office , 1st conference of the Romanian Association of Laboratory Medicine with international Participation, Cluj Napoca 18-21 May 2016, in Rev Romana Med Lab, 2016, Supl 24 (1), p.S13-S14, IF 2016 = 0.325

18. M. Dobreanu, A. Bacârea, M. Pop, C. Bănescu, V. Bacârea, Determination of reference intervals in a Romanian clinical laboratory using a posteriori techniques, W127, Clin Chem Lab Med 2015; 53, Special Suppl, pp S1153 -EuroMedLab Paris 2015 – Paris, 21-25 June 2015, DOI 10.1515/cclm-2015-5030, IF2014=2.707

19. Fodor Márta Andrea, Corina Ene, Adina Huțanu, Nicoleta Pop, Csath Mária, Ilyés Magdolna, Minodora Dobreanu, PRE-ANALYTICAL PHASE RISK EVALUATION CLINICAL LABORATORY , Ist Congress of RALM, Sighisoara 20-23 iunie 2015, in Rev Romana Med Lab, 2015, Supl 23 (1), p.S23-S24, IF 2014 = 0.239

20. Tudor Bianca, Voidăzan Septimiu, Nițu Florin, Ene Corina, Dobreanu Minodora, MONITORING OF THE STABILITY OF BIOCHEMICAL PARAMETERS TO TEMPERATURE VARIATIONS, Ist Congress of RALM, Sighisoara 20-23 iunie 2015, in Rev Romana Med Lab, 2015, Supl 23 (1), p.S32-S34.

21. Șular Floredana-Laura, Szekely Edit, Bilca Doina, Mărginean Alina, Dobreanu Minodora, DISTRIBUTION AND ANTIFUNGAL SUSCEPTIBILITY TESTING TRENDS OF CANDIDA ISOLATES – REPORT OF A SIX YEAR UNIVERSITY HOSPITAL SURVEY, Ist Congress of RALM, Sighisoara 20-23 iunie 2015, in Rev Romana Med Lab, 2015, Supl 23 (1), p.S68-S69.

22. Remona Eliza David, Carmen Delianu, Minodora Dobreanu, PREANALYTICAL ERRORS IN CLINIC LABORATORY MANAGEMENT, Ist Congress of RALM, Sighisoara 20-23 iunie 2015, in Rev Romana Med Lab, 2015, Supl 23 (1), p.S72-S73.

23. Vladimir Bacârea, Anca Bacârea, Marian Pop, Minodora Dobreanu, COMPARISON BETWEEN REFERENCE INTERVALS ON COBAS6000 AND ARCHITECT C8000 USING INDIRECT VISUAL METHOD, Ist Congress of RALM, Sighisoara 20-23 iunie 2015, in Rev Romana Med Lab, 2015, Supl 23 (1), p.S73-S74.

24. Anca Bacârea, Nicoleta Pop, Molnar Eniko, Maria Despina Baghiu, Minodora Dobreanu, ACUTE LYMPHOBLASTIC LEUKEMIA WITH CNS ONSET IN A CHILD WITH CHRONIC MYELOGENOUS LEUKEMIA – CASE REPORT, Ist Congress of RALM, Sighisoara 20-23 iunie 2015, in Rev Romana Med Lab, 2015, Supl 23 (1), p.S82-S84.

25. Alina Mărginean, Claudia Bănescu, Floredana Laura Şular, Rodica Bălașa, Smaranda Maier, Mihaela Ispas, Mariana Țăruși, Minodora Dobreanu, RESISTANCE TO ANTIPLATELET THERAPY – IS THIS A REAL PROBLEM IN ROMANIAN POPULATION ?, Ist Congress of RALM, Sighisoara 20-23 iunie 2015, in Rev Romana Med Lab, 2015, Supl 23 (1), p.S84-S85.

Cărți, capitole de cărți

1. Minodora Dobreanu et al – Culegere de teste pentru masteranzii de laborator clinic, ed. University Press – Tg.Mures, 2018, 222 pagini, ISBN 978-973-169-526-6

2. Minodora Dobreanu et al, Biochimie clinica – implicatii practice, ed. 3-a, ed. University Press – Tg.Mures, 2015, 2 volume, 458+387 pagini, ISBN 978-973-169-357-6

3. Minodora Dobreanu, Biochimie clinica – implicatii practice, ed. 2-a, ed. Medicală– București, 2010.

4. Minodora Dobreanu, Biochimie clinica – implicatii practice, ed. University Press – Tg.Mures, 2006.

5. Minodora Dobreanu - Recoltarea produselor patologice pentru examinarile de laborator, in Copotoiu Sanda, Azamfirei Leonard„Ghid de buna practica in terapia intensiva”, ed. University Press – Tg.Mures, 2008, p. 240-255.

6. Minodora Dobreanu – Cap. Biochimia sistemului nervos, in Eugen Mody, Ileana Funduc, Ruxandra Alexandrescu, - Biochimie clinică (Patochimie), ed. ALL Educational București - 2000, p.574-580

Congrese, conferinte organizate

1. al II-lea Congres al Asociaţiei de Medicina de LAborator din România cu participare internationala, Bucuresti, 9-12 MAI 2018

2. a II-a Conferinta a Asociaţiei de Medicina de Laborator din România cu participare internationala, Timisoara, 10-13 MAI 2017

3. I-a Conferinta a Asociaţiei de Medicina de Laborator din România cu participare internationala, Cluj Napoca, 18-21 MAI 2016

4. Primul Congres al Asociaţiei de Medicina de LAborator din România cu participare internationala, SIGHISOARA, 20-23 MAI 2015

5. A VIII-a Conferinta a Asociaţiei Laboratoarelor Medicale din România cu participare internationala, Sibiu, 28-31 mai 2014

6. Al II-lea Congres al Asociaţiei Laboratoarelor Medicale din România cu participare internationala, Brasov, 5-8 iunie 2013

7. A VII-a Conferinta a Asociaţiei Laboratoarelor Medicale din România cu participare internationala, Sinaia, 20-23 iunie 2012

8. A VI-a Conferinta a Asociaţiei Laboratoarelor Medicale din România cu participare internationala, Piatra Neamt, 1-4 iunie 2011

9. A V-a Conferinta a Asociaţiei Laboratoarelor Medicale din România cu participare internationala, Mamaia, 16-19 iunie 2010

10. Primul Congres al Asociaţiei Laboratoarelor Medicale din România cu participare internationala, Tirgu Mures, 24-27 iunie 2009